pKa Services Quick Facts
Assay: Acid Dissociation Constant, pKa
Method: Parallel capillary electrophoresis separation. Measurements are based on compound migration times.
Detection: UV absorbance at 229 nm
pKa Range: 1.8-11.2
Accuracy: Linear fit between multiplexed 96-capillary array CE and average of pKa values reported in the literature data demonstrated fit with r2 =0.993
Source: Dry Powder or DMSO dissolved compounds in 96 well plates, typically 15 µL,10mM concentration
Turnaround time: As little as 24 hours, typically within 5 business days
Results: Provided electronically tabulated data in Excel per customer instructions. All results are analyst-checked; internal standards included on each plate.
Experience: Developer of Automated ADME technologies since 1999 with tens of thousands of data points since 2005 for clients ranging from large pharma to small biotechs.
