Microsomal Stability

Stability in microsomes is a suitable first step in metabolic stability screening technique due to it’s low cost and high-throughput. We’ve coupled high resolution accurate mass Q-TOF MS with HPLC to help you do more with less. Full-scan data is acquired, from which narrow window extracted ion chromatograms are generated, producing quantitative data equivalent to that obtained by HPLC/MS/MS without the time-consuming process of developing distinct, MS methods for each test article. Use this data to guide structural modifications, predict in-vivo performance, develop structure-metabolic stability relationships, and triage compounds for further studies in real time.

Results can vary between species; use in-vitro data to determine which species to use in pre-clinical studies. The data below was obtained at Analiza. Commercially available compounds were tested under the same conditions using human, rat, and mouse liver microsomes.